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Thursday, October 9, 2014

IMMUNIZATION SCHEDULER

At Birth
Your baby is due to get:

BCG (Tuberculosis vaccine)

OPV (Oral polio vaccine) Dose 1

Hep B (Hepatitis B vaccine) Dose 1

6-8 weeks
Your baby is due for:

DTaP (Diphtheria, tetanus and pertussis) Dose 1 

HIB (Haemophilus Influenzae type B vaccine) Dose 1

PCV (Pneumococcal Conjugate vaccine) Dose 1
This is to prevent pneumonia and meningitis (brain fever). It is quite a costly vaccine and is given as an injection in three doses. 

Rotavirus
 Dose 1

This vaccine helps protect against rotavirus - the leading cause of diarrhoea. The WHO recommends this vaccine because the rotavirus is a major cause of dehydration in babies. 

OPV 
(Oral polio vaccine) Dose 2 


Hep B (Hepatitis B vaccine) Dose 2

Optional vaccine:

IPV (Injectible polio vaccine) Dose 1 
It is given in addition to the oral polio vaccine (OPV) and is not a substitute i.e. both can be given on the same day). 

Note: DTaP, HIB and IPV are also available as a single conjugate vaccine.

10-16 weeks
Your baby is due for:

DTaP (Diphtheria, tetanus and pertussis) Dose 2

HIB (Haemophilus Influenzae type B vaccine) Dose 2

PCV (Pneumococcal Conjugate vaccine) Dose 2

Rotavirus Dose 2
OPV (Oral polio vaccine) Dose 3 Optional vaccine:

IPV (Injectible polio vaccine) Dose 2 
It is given in addition to the oral polio vaccine (OPV) and is not a substitute i.e. both can be given on the same day).

Note:
 DTaP, HIB and IPV are also available as a single conjugate vaccine.

14-24 weeks
Your baby is due for:

DTaP (Diphtheria, tetanus and pertussis) Dose 3

Hep B (Hepatitis B vaccine) Dose 3 

HIB (Haemophilus Influenzae type B vaccine) Dose 3

PCV (Pneumococcal Conjugate vaccine) Dose 3

Rotavirus Dose 3

OPV (Oral polio vaccine) Dose 4 

Optional vaccine: 

IPV (Injectible polio vaccine) Dose 3
It is given in addition to the oral polio vaccine (OPV) and is not a substitute i.e. both can be given on the same day).

Note: DTaP, HIB and IPV are also available as a single conjugate vaccine.

6 months
Optional vaccine: 

Influenza vaccine Dose 1 
This prevents common flu to a large extent. It is administered as an injection any time after 6 months age. First timers are given 2 shots with a gap of 4 to 6 weeks. After the priming doses, one shot is given every year between October and December. This vaccine is unique, as it is specially manufactured for that particular year only, depending on the flu virus prevalent.
7-8 months
Optional vaccine: 

Influenza vaccine Dose 2
This prevents common flu to a large extent. It is administered as an injection any time after 6 months age. First timers are given 2 shots with a gap of 4 to 6 weeks. After the priming doses, one shot is given every year between October and December. This vaccine is unique as it is specially manufactured for that particular year only, depending on the flu virus prevalent.
9-12 months
Your baby is due for: 

Measles vaccine

OPV (Oral polio vaccines) Dose 5
12-18 months
Your baby is due for: 

Hep A (Hepatitis A vaccine) Dose 1 

Optional vaccine: 

Chickenpox
The chickenpox vaccine provides lifelong protection from the chickenpox virus.
15-18 months
Your baby is due for: 

MMR (Measles, mumps and rubella vaccine)

HIB (Haemophilus Influenzae type B vaccine) Booster 

DTaP (Diphtheria, tetanus and pertussis) Booster 1
18-24 months
Your baby is due for: 

OPV (Oral polio vaccine) Booster 1

Hep A (Hepatitis A vaccine) Dose 2
2 years
Your baby is due for: 

Typhoid vaccine
The vaccine will protect your baby against typhoid. Typhoid is a bacterial disease which spreads through contaminated food and water. Your baby will need a dose of this vaccine every three years. 

Optional vaccine:
 


Meningococcal meningitis

This again prevents meningitis (brain fever). It is given from 2 years age as an injection and is valid for 2 years. It is available in two varieties, one protecting against all 4 strains and the other against 2 strains. 
4-5 years
Your baby is due for: 

OPV (Oral polio vaccine) Booster 2 

Typhoid Dose 2 

MMR (measles, mumps and rubella vaccine) Booster

DTaP (Diptheria, tetanus and pertussis) Booster 2


Optional vaccine: 

Chickenpox Booster

VARICELLA VACCINE

The varicella vaccine is a live (attenuated) virus administered to protect against the viral disease commonly known as chickenpox caused by the varicella zoster virus (VZV). The varicella vaccine is marketed as Varivax in the U.S. by Merck and globally as Varilrix by GlaxoSmithKline. Another vaccine that is known as Zostavax is simply a larger-than-normal dose of Varivax, and is used in older adults to reduce the risk of shingles (also called herpes zoster) and postherpetic neuralgia that are caused by the same virus.


It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Varicella vaccine is 70% to 90% effective for preventing varicella and more than 95% effective for preventing severe varicella.[2] Furthermore, follow-up evaluations took place in the United States of children immunized that revealed protection for at least 11 years. Also, studies were conducted in Japan which indicated protection for at least 20 years.

People who do not develop enough protection when they get the vaccine may develop a mild case of the disease when in close contact with a person with chickenpox. In these cases, people show very little sign of illness. This has been the case of children who get the vaccine in their early childhood and later have contact with children with chickenpox. Some of these children may develop a mild chickenpox also known as breakthrough disease.

INFLUENZA VACCINE

The influenza vaccination is an annual vaccination using a vaccine specific for a given year to protect against the highly variable influenza virus. Each seasonal influenza vaccine contains antigens representing three (trivalent vaccine) or four (quadrivalent vaccine) influenza virus strains: one influenza type A subtype H1N1 virus strain, one influenza type A subtype H3N2 virus strain, and either one or two influenza type B virus strains.[2] Influenza vaccines may be administered as an injection, also known as a flu shot, or as a nasal spray.

The U.S. Centers for Disease Control and Prevention recommend that everyone over the ages of 6 months should receive the seasonal influenza vaccine. Vaccination campaigns usually focus on people who are at high risk of serious complications if they catch the flu, such as the elderly and people living with chronic illness or those with weakened immune systems, as well as health care workers.

Most flu vaccines provide significant protection against the virus.[5] Despite somewhat limited research, there is no evidence that they can cause serious harm, and no reason for serious side effects to be a concern.

CHOLERA VACCINE

Cholera vaccine is a vaccine used against cholera. The first vaccines used against cholera were developed in the late nineteenth century. These injected whole cell vaccines became increasingly popular until they were replaced by oral vaccines starting in the 1980s. Both oral and injectable forms are about 50-60% effective in the first year.



It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Oral cholera vaccines are increasingly used as an additional tool to control cholera outbreaks in combination with the traditional interventions to improve safe water supply, sanitation, handwashing and other means to improve hygiene. Since licensure of Dukoral and Shanchol, over a million doses of these vaccines have been deployed in various mass oral cholera campaigns around the world. In addition, Vietnam incorporates oral cholera vaccination in its public health programme and over 9 million doses have been administered through targeted mass vaccination or immunization of school-aged children in cholera endemic regions.

The cholera vaccine is largely used by backpackers and persons visiting locations where there is a high risk of cholera infection. However, since it does not provide 100% immunity from the disease, food hygiene precautions should also be taken into consideration when visiting an area where there is a high risk of becoming infected with cholera. Although the protection observed has been described as "moderate", herd immunity can multiply the effectiveness of vaccination. Dukoral has been licensed for children 2 years of age and older, Shanchol for children 1 year of age and older. The administration of the vaccine to adults confers additional indirect protection (herd immunity) to children.

The WHO recommends both preventive and reactive use of the vaccine, making the following key statements:"WHO recommends that current available cholera vaccines be used as complements to traditional control and preventive measures in areas where the disease is endemic and should be considered in areas at risk for outbreaks. Vaccination should not disrupt the provision of other high priority health interventions to control or prevent cholera outbreaks.... Reactive vaccination might be considered in view of limiting the extent of large prolonged outbreaks, provided the local infrastructure allows it, and an in-depth analysis of past cholera data and identification of a defined target area have been performed."
The WHO has now established a revolving stockpile of 2 million OCV doses. The plan is increase the size of this stockpile over the coming years with financial support of the GAVI Alliance.

YELLOW FEVER VACCINE

Yellow fever vaccine is a vaccine used against yellow fever.

The vaccine consists of a live, but attenuated, strain of the yellow fever virus called 17D. The 17D vaccine has been used commercially since the 1950s. The mechanisms of attenuation and immunogenicity for the 17D strain are not known. However, this vaccine is very safe, with few adverse reactions having been reported and millions of doses administered, and highly effective with over 90% of vaccinees developing a measurable immune response after the first dose.

In 2013, the World Health Organization concluded, "a single dose of vaccination is sufficient to confer life-long immunity against yellow fever disease."It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

TYPHOID VACCINE

Typhoid vaccines are vaccines developed to prevent typhoid fever.

There are two effective types:

Ty21a, which is a live vaccine given orally. Vi capsular polysaccharide vaccine, which is an injectable subunit vaccine. Ty21a is licensed for use from age six years and older. Boosters are recommended every 5 years. The Vi capsular polysaccharide vaccine is licensed for use from age two years and older, and boosters are required every three years.

Almroth Edward Wright developed an effective inactivated whole-cell typhoid vaccine that was introduced in 1896. Due to side-effects its usage was eventually discontinued.

An experimental vaccine called Vi-rEPA has showed promising results in trials so far, indicating higher effectiveness and longer immunity. However, it has yet to be licensed for use.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

RABIES VACCINE



Rabies vaccine is a vaccine used to control rabies. Rabies can be prevented by vaccination, both in humans and other animals. It is unusual in that it is effective even when injected after infection by the virus, which usually is noticed. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.


The human diploid cell rabies vaccine (H.D.C.V.) was started in 1967. Human diploid cell rabies vaccines are inactivated vaccines made using the attenuated Pitman-Moore L503 strain of the virus.Human diploid cell rabies vaccines have been given to more than 1.5 million people as of 2006.

Aside from vaccinating humans, another approach was also developed by vaccinating dogs to prevent the spread of the virus. In 1979 the Van Houweling Research Laboratory of the Silliman University Medical Center in Dumaguete in the Philippines, then headed by Dr. George Beran, developed and produced a dog vaccine that gave a three-year immunity from rabies. The development of the vaccine resulted in the elimination of rabies in many parts of the Visayas and Mindanao Islands. The successful program in the Philippines was later used as a model by other countries, such as Ecuador and the Yucatan State of Mexico, in their fight against rabies conducted in collaboration with the World Health Organization.


In addition to these developments, newer and less expensive purified chicken embryo cell vaccine, and purified Vero cell rabies vaccine are now available. The purified Vero cell rabies vaccine uses the attenuated Wistar strain of the rabies virus, and uses the Vero cell line as its host

Tuesday, October 7, 2014

VACCINATIONS FOR TRAVELLERS ABROAD

Vaccinations for travellers abroad 

Where further advice is required

Speak to your GP before having any vaccinations if:
  • you are pregnant
  • you are breastfeeding
  • you have an immune deficiency
  • you have any allergies

Travel vaccines information

Read more about the vaccines used to protect people travelling abroad
The following vaccinations are available for people travelling abroad:

Cholera vaccination

Vaccination against cholera is recommended for travellers to areas where the infection is widespread, particularly for aid workers and people likely to have limited access to medical services.
Most cases of cholera are confined to regions of the world with poor sanitation and water hygiene, such as parts of sub-Saharan Africa, the Indian subcontinent, South East Asia, the Middle East and South America.
The vaccine is usually given as a drink in two separate doses, taken one to six weeks apart (children aged two to six should have a third dose taken one to six weeks after the second dose). You should make sure you have the final dose of this vaccine at least a week before you travel.
A single booster dose or full re-vaccination is usually recommended if you have previously been vaccinated against cholera and you are planning to travel to an area where the infection is common.
Read more about the cholera vaccine.

Diphtheria vaccination

A combined vaccination that protects against diphtheria, polio and tetanus is routinely given to all children in the UK. You should ensure you and your children are up to date with your routine vaccinations before you travel.
Further booster doses are usually only recommended if you're going to visit parts of the world where diphtheria is widespread and your last vaccination dose was more than 10 years ago.
Areas with high rates of diphtheria include sub-Saharan Africa, South East Asia, South America and the Indian subcontinent.
Additional doses of the vaccination are given in a single 3-in-1 Td/IPV (tetanus, diphtheria and polio) injection.
Read more about the diphtheria travel vaccine.

Hepatitis A vaccination

Vaccination against hepatitis A is recommended if you're travelling to countries where hepatitis A is widespread, particularly if you are staying for a prolonged period or you are staying somewhere with poor levels of sanitation and hygiene.
Areas with a high risk of hepatitis A include Africa, the Far East, eastern Europe and the Indian subcontinent.
The vaccination against hepatitis A is usually given as a single initial injection, with an optional booster dose 6-12 months later that can protect you for at least 20 years if necessary. 
You should preferably have this initial dose at least two weeks before you leave, although it can be given up to the day of your departure if needed.
Jabs that offer combined protection against hepatitis A and hepatitis B or typhoid are also available if you are likely to also be at risk of these conditions.
Read more about the hepatitis A vaccine.

Hepatitis B vaccination

Vaccination against hepatitis B is recommended if you're travelling in parts of the world where hepatitis B is common, especially if you will be doing activities that increase your risk of developing the infection.
As hepatitis B is spread through blood and body fluids, activities such as having sex, injecting drugs or playing contact sports on your travels can increase your risk. Anyone travelling for long periods or who is likely to need medical care while abroad is also at increased risk. 
Hepatitis B is found worldwide, but it's more common in sub-Saharan Africa, most of Asia, the Pacific islands, parts of South America, southern parts of Eastern and Central Europe, the Middle East and the Indian subcontinent.
The hepatitis B vaccination generally involves a course of three injections. Depending on how quickly you need protection, these may be spread over a period as long as six months or as short as three weeks.
A combined hepatitis A and hepatitis B jab is also available if you are likely to be at risk of both these conditions while travelling.
Read more about the hepatitis B vaccine.

Japanese encephalitis vaccination

Vaccination against Japanese encephalitis is usually recommended if you're planning an extended stay (usually at least a month) in a country where the condition is widespread.
It's particularly important if you are visiting during the rainy season, if you are going to visit rural areas (such as rice fields or marshlands), or you will be taking part in any activities that may increase your risk of becoming infected (such as cycling or camping).
Japanese encephalitis is present across huge areas of Asia, stretching from the Pacific islands in the east to the borders of Pakistan in the west. It is found as far north as Korea and as far south as Papua New Guinea.
Vaccination against Japanese encephalitis usually consists of two injections, with the second dose given 28 days after the first. Ideally, you need to have the second dose a month before you leave.
Read more about the Japanese encephalitis vaccine.

Meningococcal meningitis vaccination

Vaccination against meningococcal meningitis is usually recommended if you're travelling to areas at risk and your planned activities put you at higher risk, for example if you're a long-term traveller who has close contact with the local population.
High-risk areas for meningococcal meningitis include parts of Africa and Saudi Arabia. All travellers to Saudi Arabia for the Hajj or Umrah pilgrimages are required to show proof of vaccination.
If travelling to a high-risk area, you should be vaccinated against meningococcal meningitis with an ACWY vaccine (also known as the quadrivalent meningococcal meningitis vaccine). This is given as a single injection and it should be given two to three weeks before you travel.
You should have the ACWY vaccine before travelling to high-risk areas even if you had the meningitis C vaccine as a child.
Read more about the meningococcal meningitis vaccine.

MMR (measles, mumps and rubella) vaccination

The MMR vaccine that protects against measlesmumpsand rubella is routinely given to all children in the UK. You should ensure you and your children are up to date with your routine vaccinations before you travel.
If you've not been fully vaccinated against these conditions or you're not already immune, the MMR vaccination is recommended before travelling to areas where these conditions are widespread or where there has been a recent outbreak.
The MMR vaccine is given as two injections. These are usually given when a child is 12-13 months old and when they start school. However, adults can have the two doses one month apart and children can have them three months apart if necessary.
You should ideally have the final dose at least two weeks before you leave.
Read more about the MMR vaccine.

Polio vaccination

A combined vaccination that protects against diphtheria, polio and tetanus is routinely given to all children in the UK. You should ensure you and your children are up to date with your routine vaccinations before you travel.
Further booster doses are usually only recommended if you're going to visit parts of the world where polio is widespread and your last vaccination dose was more than 10 years ago.
Currently, the condition is most common in Pakistan, Afghanistan and Nigeria, but it's also a risk in other regions of the world.
Additional doses of the vaccination are given in a single 3-in-1 Td/IPV (tetanus, diphtheria and polio) injection.
Read more about the 3-in-1 Td/IPV vaccine.

Rabies vaccination

Vaccination against rabies is advised if you're travelling to an area where rabies is common in animals, particularly if you are staying for a month or more, there is limited access to medical services and you will be carrying out activities that could expose you to rabies (such as cycling or running).
Rabies can be found in many parts of the world, including the Middle East, Africa, Asia, Central and South America, and some parts of Eastern Europe.
Vaccination usually requires a course of three injections. The second dose is given seven days after the first and the third dose is given 14-21 days after the second.
Further doses are not usually recommended for travellers, unless it has been more than 10 years since you were first vaccinated and you are visiting an area with a high risk of rabies.
Read more about the rabies vaccine.

Tetanus vaccination

A combined vaccination that protects against diphtheria, polio and tetanus is routinely given to all children in the UK. You should ensure you and your children are up to date with your routine vaccinations before you travel.
Further booster doses are usually only recommended if you're travelling to areas where access to medical services is likely to be limited or your last vaccination dose was more than 10 years ago.
Additional doses of the vaccination are given in a single 3-in-1 Td/IPV (tetanus, diphtheria and polio) injection.
Read more about the 3-in-1 Td/IPV vaccine.

Tick-borne encephalitis vaccination

Vaccination against tick-borne encephalitis (TBE) is usually recommended for anyone who plans to live or work in a high-risk area, or hike and camp in these areas during late spring or summer.
The ticks that cause TBE are mainly found in forested areas of central, eastern and northern Europe, although at-risk areas also include eastern Russia and some countries in East Asia (particularly forested regions of China and Japan).
The vaccination requires a course of three injections for full protection. The second dose is given one to three months after the first and provides immunity for about one year. A third dose, given 5-12 months after the second, provides immunity for up to three years.
The course can sometimes be accelerated if necessary. This involves two doses being given two weeks apart.
Booster doses of the vaccine are recommended every three years if necessary.
Read more about the tick-borne encephalitis vaccine.

Tuberculosis (TB) vaccination

Vaccination against tuberculosis (TB) is given to some children in the UK who are at increased risk from tuberculosis.
For travellers, the BCG vaccination (which protects against TB) is recommended for people under 16 years old who will be living or working with local people for three months or more and have not been previously vaccinated.
Parts of the world that have high rates of TB include sub-Saharan and west Africa, South East Asia, Russia, China, South America and the western Pacific region.
The BCG vaccine is given as a single injection.
Read more about the BCG vaccine.

Typhoid vaccination

Vaccination against typhoid fever is recommended if you are travelling to parts of the world where the condition is common, particularly if you will be staying or working with local people or you will have frequent or prolonged exposure to conditions where sanitation and food hygiene are likely to be poor.
High-risk areas include parts of Africa, Central America, the Indian subcontinent, the Middle East, South America and South and South East Asia.
Two main vaccines are available for typhoid fever in the UK. One is given as a single injection and one is given as three capsules to take on alternate days. It is also possible to have a combined hepatitis A and typhoid jab.
Ideally, the typhoid vaccine should be given at least one month before you travel, but it can be given closer to your travel date if necessary.
The protective effect of the injectable vaccine lasts about three years. After that time, another injection is necessary. The long term protection after a booster dose is not known.
A booster dose is recommended one year after the oral vaccine unless you remain in an area of risk, when a boost at three years may be sufficient.
Read more about the typhoid vaccine.

Yellow fever vaccination

Vaccination against yellow fever is advised if you're travelling to areas where there's a risk of yellow fever transmission. Some countries require proof of vaccination certificate before they let you enter the country.
Yellow fever is most common in some areas of tropical Africa and South America.
A booster dose of the yellow fever vaccine is currently recommended every 10 years if you are still at risk. However, this is likely to change in the future as recent evidence suggests that a single dose offers life-long protection.
You must have a yellow fever vaccination at least 10 days before you travel.
Read more about the yellow fever vaccine.

Sunday, October 5, 2014

VACCINES (IMMUNIZATIONS)

Vaccines (immunizations) - overview

Vaccines are used to improve your immune system and prevent serious, life-threatening diseases.

Information

HOW VACCINES WORK
Vaccines "teach" your body how to defend itself when germs, such as viruses or bacteria, invade it:
  • They expose you to a very small, very safe amount of viruses or bacteria that have been weakened or killed.
  • Your immune system then learns to recognize and attack the infection if you are exposed to it later in life.
  • As a result, you will not become ill or you may have a milder infection. This is a natural way to deal with infectious diseases.
Four types of vaccines are currently available:
  • Live virus vaccines use the weakened (or attenuated) form of the virus. The measles, mumps, and rubella (MMR) vaccine and the varicella (chickenpox) vaccine are examples.
  • Killed (inactivated) vaccines are made from a protein or other small pieces taken from a virus or bacteria. The flu vaccine is an example.
  • Toxoid vaccines contain a toxin or chemical made by the bacteria or virus. They make you immune to the harmful effects of the infection, instead of to the infection itself. Examples are the diphtheria and tetanus vaccines.
  • Biosynthetic vaccines contain manmade substances that are very similar to pieces of the virus or bacteria. The Hib (Haemophilus influenzae type B) conjugate vaccine is an example.
WHY WE NEED VACCINES
For a few weeks after they are born, babies have some protection from germs that cause diseases. This protection is passed from their mother through the placenta before birth. After a short period, this natural protection goes away.
Vaccines help protect against many diseases that used to be much more common. Examples include tetanus, diphtheria, mumps, measles, pertussis (whooping cough), meningitis, and polio. Many of these infections can cause serious or life-threatening illnesses and may lead to lifelong disabilities. Because of vaccines, many of these illnesses are now rare.
SAFETY OF VACCINES
Some people worry that vaccines are not safe and may be harmful, especially for children. They may ask their health care provider to wait or even choose not to have the vaccine. But the benefits of vaccines far outweigh their risks.
Scientific studies have shown that vaccines and their components, such as the preservative thimerosal, do not cause autism or ADHD. Based on these studies, the American Academy of Pediatrics, the Centers for Disease Control and Prevention, as well as the Institute of Medicine conclude that the benefits of vaccines outweigh their risks.
Other information about risks:
  • Getting the actual infection from vaccines: Unless a person's immune system is weakened, it is unlikely that a vaccine will give the person the infection. Vaccines, such as the measles, mumps, rubella, the chickenpox, and nasal spray flu contain live but weakened viruses and should not be received by persons with weakened immune systems.
  • Allergic reactions: Such reactions are rare and are usually to some part (component) of the vaccine. 
  • Danger of live vaccines: Certain live vaccines may be dangerous to the fetus of a pregnant woman. These include the measles, mumps, rubella vaccine, the chickenpox vaccine, and the nasal spray flu vaccine. To avoid harm to the baby, pregnant women should not receive any of these vaccines. The health care provider can tell you the right time to get these vaccines.
VACCINE SCHEDULE
The recommended vaccination (immunization) schedule is updated every 12 months by the U.S. Centers for Disease Control and Prevention (CDC). Talk to your health care provider about specific immunizations for you or your child. Current recommendations are available at the CDC website: http://www.cdc.gov/vaccines/schedules.
TRAVELERS
The CDC website (http://www.cdc.gov/travel/page/vaccinations.htm) has detailed information on immunizations and other precautions for travelers to other countries. Many immunizations should be received at least one month before travel.
Bring your immunization records with you when you travel internationally. Some countries require this documentation.